【产品介绍】：

产品名称 AT406 (SM-406) 英文名称 AT406 (SM-406) 规格或纯度 ≥98% 英文别名 (5S,8S,10aR,Z)-N-benzhydryl-5-((Z)-((S)-1-hydroxy-2-(methylamino)propylidene)amino)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carbimidic acid；ARRY-334543, Debio1143, SM-406 ;(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanami 运输条件 超低温冰袋运输 生化机理 AT-406 (formerly known as SM-406) is an orally bioavailable potent IAP (inhibitor of apoptosis protein) of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively. This may restore and promote the induction of apoptosis throμgh apoptotic signaling pathways. AT-406 may work synergistically with cytotoxic drμgs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains. AT-406 is currently in Phase I clinical trial in patients with advanced solid tumors and lymphomas.CAS编号 1071992-99-8 溶解性 DMSO 100 mg/mL Water <1 mg/mL Ethanol 100 mg/mL 储存温度 -20°C储存 分子量 561.71 分子式 C32H43N5O4 PubChem CID 25022340