【产品介绍】：

产品名称 塞马西尼 英文名称 SU5416 应用 It was used to study the mechanism of development of cerebral vasculature in zebrafish hindbrain，and study the pulmonary vascular remodeling in response to hypoxia in mouse model of pulmonary arterial hypertension. 规格或纯度 ≥98% (HPLC) 别名 SU-5416;SU5416 英文别名 Semaxinib;SU-5416;VEGFR2 Kinase Inhibitor III; 1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one 运输条件 超低温冰袋运输 生化机理 VEGFR2 Kinase Inhibitor III is a cell-permeable ATP-competitive inhibitor of Flk-1 (VEGFR2/KDR, kinase insert domain receptor), which is the major growth factor for vascular endothelial cells. This receptor is a type III tyrosine kinase receptor that functions as the main mediator of VEGF-induced endothelial proliferation, survival, and migration. Studies sμggest that VEGFR2 Kinase Inhibitor III also inhibits a variety of other receptors such as Met, Flt-3/Flk-2 (FLT-3 receptor tyrosine kinases), Ret, c-Kit, PDGFR, c-Abl and Arg (ABL), and ALK. In addition, VEGFR2 kinase inhibitor III regulates the signaling pathways used by oncogenic RET-transfected cells by regulating the extracellular signal regulated kinase (ERK) and JNK pathways.CAS编号 204005-46-9 熔点 221-222°C 溶解性 Soluble in DMSO (5 mg/ml), and ethanol (100 mM). Insoluble in water. 储存温度 -20°C储存 MDL号 MFCD01940922 分子量 238.28 分子式 C15H14N2O PubChem CID 5329098