【产品介绍】：

产品名称 HA14-1 英文名称 HA14-1 应用 A cell-permeable, nonpeptidic Bcl-2 inhibitor 规格或纯度 ≥98% 别名 HA-14-1; HA 14-1 英文别名 HA-14-1; HA 14-1;2-amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphar,4r)-rel-4h-1-benzopyran-4-acetic acid ethyl ester；Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate 运输条件 超低温冰袋运输 生化机理 HA14-1 is a small molecule and nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of approximately 9 μM. HA14-1 induces the apoptosis of HL-60 cells in a dose-dependent manner via caspase activation. HA14-1 shows cytotoxic effects on HF1A3, HF4.9 and HF28RA follicular lymphoma B cell lines with LC50 of 4.5 μM, 12.6 μM and 8.1 μM respectively. HA14-1 induces apoptosis of HF1A3, HF4.9 and HF28RA cells via caspase and ROS.Cell permeable Bcl-2 inhibitor. BH-3 mimetic. Disrupts Bax and Bcl-2 interactions. Apoptotic anticancer agent.CAS编号 65673-63-4 折光率 1.57 熔点 105-108°C 沸点 535.1° C at 760 mmHg 溶解性 DMSO 储存温度 -20°C储存 分子量 409.23 分子式 C17H17BrN2O5 PubChem CID 3549