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Sulfo DBCO-PEG4-amine
作者：德尔塔 日期：2022-08-30
产品描述 Sulfo DBCO-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 靶点活性 PEGs 体外活性 PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].分子量 678.79 分子式 C32H46N4O10S CAS No. 2055198-05-3存储
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Dde Biotin-PEG4-DBCO
作者：德尔塔 日期：2022-08-30
产品描述 Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 靶点活性 PEGs 体外活性 PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].分子量 872.08 分子式 C47H61N5O9S CAS No. 1807512-43-1存储
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DBCO-PEG4-NHS ester
作者：德尔塔 日期：2022-08-30
产品描述 DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 靶点活性 PEGs 体外活性 PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].纯度 95.00% 分子量 649.69 分子式 C34H39N3O10
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DBCO-Val-Cit-OH
作者：德尔塔 日期：2022-08-30
产品描述 DBCO-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. 靶点活性 Cleavable 体外活性 ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].分子量 589.68 分子式 C32H39N5O6 CAS No. T17814存储 Powder: -20°C for 3 years In solvent: -80°C f
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DBCO-Sulfo-Link-biotin
作者：德尔塔 日期：2022-08-30
产品描述 DBCO-Sulfo-Link-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. 靶点活性 Cleavable 体外活性 ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.分子量 653.77 分子式 C31H35N5O7S2 CAS No. 1363444-70-5存储 Powder: -20°C for 3 years In solvent:
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DBCO-NHCO-PEG4-amine
作者：德尔塔 日期：2022-08-30
产品描述 DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1]. 靶点活性 Cleavable 体外活性 ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.分子量 523.62 分子式 C29H37N3O6 CAS No. 1255942-08-5存储
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DBCO-NHS ester 3
作者：德尔塔 日期：2022-08-30
产品描述 DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2]. 靶点活性 Cleavable分子量 416.43 分子式 C24H20N2O5 CAS No. 1393350-27-0存储 Powder: -20°C for 3 years In solvent: -80°C for 2 years 溶解度
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DBCO-C3-Acid
作者：德尔塔 日期：2022-08-30
产品描述 DBCO acid 2 is a Click Chemistry intermidate used for antibody-drug conjugates.别名 DBCO-(CH2)3-Acid , 纯度 97.42% 分子量 319.35 分子式 C20H17NO3 CAS No. 1207355-31-4存储 Powder: -20°C for 3 years In solvent: -80°C for 2 years
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DBCO-NHS ester 2
作者：德尔塔 日期：2022-08-30
产品描述 DBCO-NHS ester 2 is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 2 is a derivative of Dibenzylcyclooctyne (DBCO) used in copper-free click chemistry[1]. 靶点活性 Others分子量 430.45 分子式 C25H22N2O5 CAS No. 1384870-47-6存储 Powder: -20°C for 3 years In solvent: -80°C for 2 years 溶解度
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DM1-PEG4-DBCO
作者：德尔塔 日期：2022-08-30
产品描述 DM1-(PEG)4-DBCO is a drug-linker conjugate composed of a potent microtubulin inhibitor DM1 and a linker DBCO-PEG4-Ahx to make antibody drug conjugate (ADC). Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. 靶点活性 Maytansinoids分子量 1198.79 分子式 C63H80ClN5O16 CAS No. T17832存储 Powder: -20°C for 3 years In solvent: -80°C for 2 years 溶解度
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DBCO-PEG4-Biotin
作者：德尔塔 日期：2022-08-30
产品描述 DBCO-PEG4-Biotin is a versatile biotinylation reagent used for the introduction of a biotin moiety to azide-labeled biomolecules via copper-free strain-promoted alkyne-azide click chemistry (SPAAC) reaction. 靶点活性 Others分子量 749.92 分子式 C39H51N5O8S CAS No. 1255942-07-4存储 Powder: -20°C for 3 years In solvent: -80°C for 2 years 溶解度
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DBCO-PEG4-alkyne
作者：德尔塔 日期：2022-08-30
产品描述 DBCO-PEG4-alkyne is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. 靶点活性 Non-cleavable 体外活性 ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].分子量 518.6 分子式 C30H34N2O6 CAS No. T17795存储 Powder: -20°C for 3 years In s
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DBCO-PEG3-TCO
作者：德尔塔 日期：2022-08-30
产品描述 DBCO-PEG3-TCO is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. 靶点活性 Non-cleavable 体外活性 ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].分子量 631.76 分子式 C36H45N3O7 CAS No. T17792存储 Powder: -20°C for 3 years In sol
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DBCO-PEG3-oxyamine
作者：德尔塔 日期：2022-08-30
产品描述 DBCO-PEG3-oxyamine is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. 靶点活性 Non-cleavable 体外活性 ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].分子量 552.62 分子式 C29H36N4O7 CAS No. T17790存储 Powder: -20°C for 3 years I
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APN-PEG4-DBCO
作者：德尔塔 日期：2022-08-30
产品描述 APN-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. 靶点活性 Cleavable 体外活性 ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].分子量 676.76 分子式 C39H40N4O7 CAS No. T17451存储 Powder: -20°C for 3 years In solvent:
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