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Cy5.5-SE
作者：德尔塔 日期：2022-09-26
Cy5.5-SE 是一种花青染料，可标记多肽、蛋白和寡核苷酸中的氨基。Cy5.5-SE is a cyanine dye, labeling amino-groups in peptides, proteins, and oligonucleotides.Cy5.5-SE is a cyanine dye, labeling amino-groups in peptides, proteins, and oligonucleotides.Cas No. 442912-55-2 SDF 别名 N/A 化学名 N/A Canonical SMILES O=S(C1=CC(S(=O)([O-])=O)=C2C(C3=C([N+](CC)=C(/C=C/C=C/C=C4N(CCCCCC(ON5C(CCC5=O)=O)=O)C6=C(C7=CC(S(=O)(O)=O)=CC(S(=O)(O)=O)=C7C=C6)C/4(C)C)C3(C)C)C=C2)=C1)(O)=O 分子式 C45H47N3O16S4 分子量 1014.13 溶解度 Soluble in DMSO 储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
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Cy5.5 NHS ester (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Cy5.5-NHS ester is a near-infrared amine reactive dye for labeling amino groups of peptides, proteins and oligonucleotides.Quality Control & SDS View current batch: 54321 Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet jQuery(document).ready(function(){ jQuery('#selectqc').change(function(){ var val = jQuery(this).val(); show_or_hidden(val,5); }) }); Quality Control & SDS View current batch: 54321 Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet jQuery(document).ready(function(){ jQuery('#selectqc').change(function(){ var val = jQuery(this).val(); show_or_hidden(val,5); }) });Cell experiment [1]:Cell lines U87MGPreparation Method U87MG cells (1 ×
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Cy5.5 hydrazide (non-sulfonated)
作者：德尔塔 日期：2022-09-26
carbonyl-reactive dyeCy5.5 hydrazide is a reactive dye for the labeling of biomolecules containing carbonyl groups, such as ketone and aldehydes. This dye pocesses a hydrazide group that can be used to label glycans at their reducing end or other reducing sugars, forming a hydrazone linkage. Hydrazide-containing Cyanine Dyes can react with glycoproteins and other glycoconjugates specifically via their carbohydrate groups without interfering binding site or active centers. Glycoproteins also can be labeled after periodate oxidation to form aldehyde groups. Therefore, this dye is especially applicable for the labeling of antibody. Moreover, Cy5.5 is a near infrared fluorophore with prominent ability of tissue penetration, so it is suitable for the applications which require low fluorescence background, and for the in vivo NIR imaging. For biomolecule labeling, the labeling regent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer.Cy5.5 hydrazide is a reactive dye for the labeling of biomolecules containing carbonyl groups, such as ketone and aldehydes. This dye pocesses a hydrazide group that can be used to label glycans at their reducing end or other reducing sugars, forming a hydrazone linkage. Hydrazide-containing Cyanine Dyes can react with glycoproteins and other glycoconjugates specifically via their carbohydrate groups without interfering binding site or active centers.
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Cy5.5 carboxylic acid (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Non-reactive fluorophore, for control experiments, and for calibrationCy5.5 carboxylic acid is an un-activated labeling regent which has low aqueous solubility. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. Cyanine 5.5 carboxylic acid instead of the drug was injected into the tumors in order to visually observe the dye release by using the in vivo imaging system (IVIS). Research show that NIR irradiation could efficiently triggered drug release from the DEPt-PEG/α-CD hydrogel in vivo [1].Reference:[1] Wang, X. ; Wang, C.; Zhang, Q.; Cheng, Y. Near Infrared Light-responsive and Injectable Supramolecular Hydrogels for On-demand Drug Delivery. Chemical Communications, 2016, 52, 978–981.Cy5.5 carboxylic acid is an un-activated labeling regent which has low aqueous solubility. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. Cyanine 5.5 carboxylic acid instead of the drug was injected into the tumors in order to visually observe the dye release by using the in vivo imaging system (IVIS). Research show that NIR irradiation could efficiently triggered drug release from the DEPt-PEG/α
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Cy5.5 azide (non-sulfonated)
作者：德尔塔 日期：2022-09-26
used for Click chemistry to label alkyne-modified oligonucleotidesThis Cy5.5 is a labeling reagent that ready for the use in Click Chemistry reaction which available as 10 mM solution in DMSO. As Cy5.5 azide is a far-red emitting dye, it can replace Alexa Fluor 680, and DyLight 680. Most derivatives of non-sulfonated cyanines have low aqueous solubility except for hydrochlorides of hydrazides and amines. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. In human glioblastoma U87MG cells, to assess the capability of the Cu(I)/M-dots for cell labeling Cy5.5-azide was in combination with Cu(I)/M-dots for imaging of the integrin αⅤβ3 receptor [1].Reference:[1] Sun, Y. ; Hong, S.; Ma, X.; Cheng, K.; Wang, J.; Zhang, Z.; Yang, M.; Jiang, Y.; Hong, X.; Cheng, Z. Recyclable Cu(I)/Melanin Dots for Cycloadditions, Bioconjugation and Cell Labeling. Chemical Science.This Cy5.5 is a labeling reagent that ready for the use in Click Chemistry reaction which available as 10 mM solution in DMSO. As Cy5.5 azide is a far-red emitting dye, it can replace Alexa Fluor 680, and DyLight 680. Most derivatives of non-sulfonated cyanines have low aqueous solubility except for hydrochlorides of hydrazides and amines. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is nec
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Cy5.5 alkyne (non-sulfonated)
作者：德尔塔 日期：2022-09-26
远红外/近红外染料，用于点击化学标记Cy5.5 alkyne (non-sulfonated)是一种远红外/近红外染料炔，含有乙炔基，用于点击化学标记。Cyanine5.5是Cy5.5®的类似物，Cy5.5®是一种常见的荧光团，被广泛用于各种应用，包括完整的生物体成像。Cy5.5 alkyne (non-sulfonated)在温和铜催化的点击化学条件下可以与叠氮基团结合。Cy5.5 alkyne (non-sulfonated)可溶于有机溶剂，但水与小百分比的DMSO混合物可用于有效的缀合反应。Cy5.5 alkyne (non-sulfonated)也可用于标记小分子。Cy5.5 alkyne (non-sulfonated)是一种远红外/近红外染料炔，含有乙炔基，用于点击化学标记。Cyanine5.5是Cy5.5®的类似物，Cy5.5®是一种常见的荧光团，被广泛用于各种应用，包括完整的生物体成像。Cy5.5 alkyne (non-sulfonated)在温和铜催化的点击化学条件下可以与叠氮基团结合。Cy5.5 alkyne (non-sulfonated)可溶于有机溶剂，但水与小百分比的DMSO混合物可用于有效的缀合反应。Cy5.5 alkyne (non-sulfonated)也可用于标记小分子。Cas No. N/A SDF 别名 N/A 化学名 N/A Canonical SMILES CN1C2=CC=C3C=CC=CC3=C2C(C)(C)/C1=C\C=C\C=C\C4=[N+](CCCCCC(NCC#C)=O)C5=CC=C(C=CC=C6)C6=C5C4(C)C.[Cl-] 分子式 C43H46ClN3O 分子量 656.3 溶解度 >65.6 mg/mL in DMSO; insoluble in H2O; >13 mg/mL in EtOH 储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while
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Cy5.5
作者：德尔塔 日期：2022-09-26
Cy5.5 (Sulfo-Cyanine5.5) 是用于标记生物分子的近红外荧光染料 (Ex=673 nm, Em=707 nm)，如肽，蛋白质和寡核苷酸。Cy5.5 (Sulfo-Cyanine5.5) is a near-infrared fluorescent dye (Ex=673 nm, Em=707 nm) used to label biological molecules, such as peptides, proteins, and oligonucleotides[1].[1]. Zhu S, et al. Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody. J Drug Target. 2015 Apr;23(3):257-65. [2]. Jiang L, et al. pH/temperature sensitive magnetic nanogels conjugated with Cy5.5-labled lactoferrin for MR and fluorescence imaging of glioma in rats. Biomaterials. 2013 Oct;34(30):7418-28. [3]. Lim B, et al. A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombosis and Pulmonary Embolism Using a Novel Three-Dimensional Fluorescence Emission Computed Tomography (FLECT) Technology. Theranostics. 2017 Feb 26;7(5):1047-1061.Cy5.5 (Sulfo-Cyanine5.5) is a near-infrared fluorescent dye (Ex=673 nm, Em=707 nm) used to label biological molecules, such as peptides, proteins, and oligonucleotides[1].[1]. Zhu S, et al. Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody. J Drug Target. 2015 Apr;23(3):257-65. [2]. Jiang L, et al. pH/temperature sensitive magnetic nanogels conjugated with Cy5.5-labled lactoferrin for MR and fluorescence imaging of glioma in rats. Biomaterials. 2013 Oct;34(30):7418-28. [3]. Lim B, et al. A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombo
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CY5-YNE
作者：德尔塔 日期：2022-09-26
CY5-YNE是一种用于标记肽,蛋白质,寡核苷酸的氨基基团的反应染料。CY5-YNE is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides.CY5-YNE is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides.Cas No. 1345823-20-2 SDF 别名 N/A 化学名 N/A Canonical SMILES CC(/C(N1CCCCCC(NCC#C)=O)=C\C=C\C=C\C2=[N+](CC)C(C=CC(S(=O)([O-])=O)=C3)=C3C2(C)C)(C)C4=C1C=CC(S(=O)(O)=O)=C4 分子式 C36H43N3O7S2 分子量 693.87 溶解度 DMSO : ≥ 43 mg/mL (61.97 mM) 储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
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Cy5-SE (triethylamine salt)
作者：德尔塔 日期：2022-09-26
Cy5-SE is a hydrophilic amine-reactive fluorescent probe.1 It displays excitation/emission maxima of 646/662 nm, respectively. Cy5-SE-conjugated ligands have been used in the characterization of hematopoietic tumor microenvironments.1.Soodgupta, D., Zhou, H., Beaino, W., et al.Ex vivo and in vivo evaluation of overexpressed VLA-4 in multiple myeloma using LLP2A imaging agentsJ. Nucl. Med.57(4)640-645(2016)Cy5-SE is a hydrophilic amine-reactive fluorescent probe.1 It displays excitation/emission maxima of 646/662 nm, respectively. Cy5-SE-conjugated ligands have been used in the characterization of hematopoietic tumor microenvironments.1.Soodgupta, D., Zhou, H., Beaino, W., et al.Ex vivo and in vivo evaluation of overexpressed VLA-4 in multiple myeloma using LLP2A imaging agentsJ. Nucl. Med.57(4)640-645(2016)Cas No. 1497420-70-8 SDF 别名 N/A 化学名 N/A Canonical SMILES O=C(CCCCCN1/C(C(C)(C2=C1C=CC(S(O)(=O)=O)=C2)C)=C/C=C/C=C/C3=[N+](C4=CC=C(C=C4C3(C)C)S([O-])(=O)=O)CC)ON5C(CCC5=O)=O.CCN(CC)CC 分子式 C37H43N3O10S2.C6H15N 分子量 855.1 溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 15 mg/ml,PBS (pH 7.2): 1 mg/ml 储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it
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CY5-SE
作者：德尔塔 日期：2022-09-26
Cy5-SE是一种用于标记肽, 蛋白质, 寡核苷酸的氨基基团的反应染料。激发波长 (nm): 649, 发射波长 (nm): 670。Cy5-SE is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling.Excitation (nm):649, Emission (nm): 670.Cy5-SE is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling.Excitation (nm):649, Emission (nm): 670.Cas No. 146368-14-1 SDF 别名 Cy5 NHS Ester 化学名 N/A Canonical SMILES CC(/C(N1CCCCCC(ON2C(CCC2=O)=O)=O)=C\C=C\C=C\C3=[N+](CC)C(C=CC(S(=O)([O-])=O)=C4)=C4C3(C)C)(C)C5=C1C=CC(S(=O)(O)=O)=C5 分子式 C37H43N3O10S2 分子量 753.88 溶解度 DMSO: 25 mg/mL (33.16 mM) 储存条件
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Cy5-PEG3-azide
作者：德尔塔 日期：2022-09-26
Cy5-PEG3-azide是一种PROTAClinker，属于PEG类。可用于合成PROTAC分子。Cy5-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562Cy5-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562Cas No. N/A SDF 别名 N/A 化学名 N/A Canonical SMILES CC(C1=CC=CC=C1N/2C)(C)C2=C/C=C/C=C/C3=[N+](CCCCCC(NCCOCCOCCOCCN=[N+]=[N-])=O)C(C=CC=C4)=C4C3(C)C.[Cl-] 分子式 C40H55ClN6O4 分子量 719.36
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CY5-N3
作者：德尔塔 日期：2022-09-26
CY5-N3是一种Cy5-叠氮化物，是一种荧光染料。CY5-N3 is a Cy5-azide, which is a fluorescent dye.CY5-N3 can be used to monitor the CuAAC of branched DNA with Cy5-azide by HPLC[1].[1]. Finke A, et al. Designer Extracellular Matrix Based on DNA-Peptide Networks Generated by Polymerase ChainReaction. Angew Chem Int Ed Engl. 2016 Aug 16;55(34):10136-40.CY5-N3 is a Cy5-azide, which is a fluorescent dye.CY5-N3 can be used to monitor the CuAAC of branched DNA with Cy5-azide by HPLC[1].[1]. Finke A, et al. Designer Extracellular Matrix Based on DNA-Peptide Networks Generated by Polymerase ChainReaction. Angew Chem Int Ed Engl. 2016 Aug 16;55(34):10136-40.Cas No. 1621101-43-6 SDF 别名 N/A 化学名 N/A Canonical SMILES CC1(C)/C(N(C2=CC=C(S(=O)(O)=O)C=C21)CCCCCC(NCCCN=[N+]=[N-])=O)=C\C=C\C=C\C(C(C)(C3=CC(S(=O)([O-])=O)=CC=C43)C)=[N+]4CC 分子式 C36H46N6O7S2 分子量 738.92 溶解度 DMSO : 25 mg/mL (33.83 mM) 储存条件 Store at -20°C,unstable in solution, ready to use. General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice
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Cy5 NHS ester(Et)
作者：德尔塔 日期：2022-09-26
氨基反应性荧光染料，溶于水Cas No. N/A SDF 别名 N/A 化学名 N/A Canonical SMILES CC1(C)C2=C(C=CC(S(=O)([O-])=[O-])=C2)[N+](CCCCCC(ON3C(CCC3=O)=O)=O)=C1/C=C/C=C/C=C4N(CC)C5=CC=C(S(=O)([O-])=O)C=C5C/4(C)C.[Na+] 分子式 C37H42N3NaO10S2 分子量 775.86 溶解度 insoluble in EtOH; >1.5 mg/mL in H2O with ultrasonic; >16.67 mg/mL in DMSO 储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
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Cy5 NHS ester (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Labeling of amino-groups in biomolecules.Cyanine5 NHS ester is a ideal reactive dye for the labeling of peptides, proteins, and oligonucleotides which contain the amino-groups. Recently, among the life science research and diagnostics, Dye color quantity can be detected in gel electrophoresis by naked eye as the dye color is very intense and as small as 1 nanomol. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. For more sophisticated targets such as easily degradable proteins, when use of DMF or DMSO is undesirable, consider using water-soluble Cy5 NHS ester which does not require co-solvent, and has very similar fluorescent properties.In mice, Cy5-labeled polyplexes was intravenous injected to evaluate the targeting ability of polyplexes in tumor-bearing nude mice. Heart, liver, spleen, lung, kidney and tumor, were removed after the mice were sacrificed and the fluorescence intensities of Cy5-labeled polyplexes were immediately examined [1].Reference:[1] Chen, K. ; Chen, Q.; Wang, K.; Zhu, J.; Li, W.; Li, W.; Qiu, L.; Guan, G.; Qiao, M.; Zhao, X.; Hu, H.; Chen, D. Synthesis and characterization of a PAMAM-OH derivative containing an acid-labile β-thiopropionate bond for gene delivery. International Journal of Pharmaceutics, 2016, 509(1–2), 314–327.Cyanine5 NHS ester is a ideal reactive dye for the labeling of peptides, protei
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Cy5 NHS ester
作者：德尔塔 日期：2022-09-26
Labeling of amino-groups in biomolecules.Sulfo-Cy5 NHS ester is a sulfonated, hydrophilic and highly water soluble dye. For the labeling of various amine-containing molecules in aqueous phase, no organic co-solvent is needed. This regent is especially useful for the labeling of proteins which denaturate in the presence of organic co-solvents, as well as for proteins with low solubility. Sulfo-Cy5 NHS ester is one of the most popular fluorophores. In life science, the sulfonate groups make the Cy dyes soluble in water and also reduce fluorescence-quenching which can arise from dye-dye interactions.Sulfo-Cy5 NHS ester, was conjugated to LLP2A with 646/662 peak excitation/emission in dimethyl sulfoxide. LLP2A exhibited punctate staining around the cell periphery, consistent with it labeling VLA-4 [1].Reference:[1] Soodgupta, D. ; Zhou, H.; Beaino, W.; Lu, L.; Rettig, M.; Snee, M.; Skeath, J.; DiPersio, J.F.; Akers, W.J.; Laforest, R.; Anderson, C.J.; Tomasson, M.H.; Shokeen, M. Ex Vivo and In Vivo Evaluation of Overexpressed VLA-4 in Multiple Myeloma Using LLP2A Imaging Agents. Journal of Nuclear Medicine, 2016, 57(4), 640–645.Sulfo-Cy5 NHS ester is a sulfonated, hydrophilic and highly water soluble dye. For the labeling of various amine-containing molecules in aqueous phase, no organic co-solvent is needed. This regent is especially useful for the labeling of proteins which denaturate in the presence of organic co-solvents, as well as for proteins with low solubility. Sulfo-Cy5 NHS ester is one of the most popular fluorophores. In life science, the sulfonate groups make the C
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