【产品介绍】：

产品名称 TW-37 英文名称 TW-37 规格或纯度 ≥99% 别名 5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide 英文别名 5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide 运输条件 超低温冰袋运输 生化机理 TW-37 is Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). TW-37 inhibits the angiogenic potential of endothelial cells in vitro. TW-37 induces S-phase arrest and apoptosis in pancreatic cancer cell lines; also inhibits the activation of Notch-1 and Jagged-1 in vitro and in vivo.Small-molecule inhibitor of BCL-2 ( K i = 0.29 μM). Inhibits multiple BCL-2 family members including BCL-XL ( K i =\xa01.11\xa0μM) and MCL-1 ( K i = 0.26 μM). Binds to the BCL-2 homology domain 3 (BH3) groove of BCL-2.CAS编号 877877-35-5 溶解性 DMSO 115 mg/mL Water <1 mg/mL Ethanol 4 mg/mL 储存温度 -20°C储存 分子量 573.71 分子式 C33H35NO6S