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CAS:1418308-27-6|EI1
作者：德尔塔 日期：2022-03-14
产品名称 EI1 英文名称 EI1 规格或纯度 ≥96% 别名 EI-1;EI 1 英文别名 Ezh2 inhibitor；6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide 运输条件 超低温冰袋运输 生化机理 EI1 demonstrated potent, concentration-dependent inhibition of the enzymatic activity against both Ezh2 wild-type and Y641F mutant enzymes with IC50 of 15 ± 2 nM and 13 ± 3 nM, respectively. Althoμgh SAM is the common cofactor for all HMTs, EI1 showed remarkable selectivity against Ezh2 over other HMTs. EI1 dramatically inh
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CAS:759-73-9|1-乙基-1-亚硝基脲
作者：德尔塔 日期：2022-03-14
产品名称 1-乙基-1-亚硝基脲 英文名称 1-Ethyl-1-nitrosourea 应用 A precursor of Diazoethane 别名 ENU 生化机理 DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.CAS编号 759-73-9 敏感性 比旋光度
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CAS:1596-84-5|丁酰肼
作者：德尔塔 日期：2022-03-14
产品名称 UNC1999 英文名称 UNC1999 规格或纯度 ≥98% 别名 UNC-1999;UNC 1999 英文别名 UNC-1999;UNC 1999;n-((1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl)-1-(1-methylethyl)-6-(6-(4-(1-methylethyl)-1-piperazinyl)-3-pyridinyl)-1h-indazole-4-carboxamide; 1-Isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-p 运输条件 超低温冰袋运输 生化机理 UNC1999 was the first orally bioavailable EZH2 inhibitor that has high in vitro potency for wild-type and mutant EZH2 as well as EZH1, UNC1999 was highly selective for EZH2 and EZH1 over a broad range of e
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CAS:1431612-23-5|UNC1999
作者：德尔塔 日期：2022-03-14
产品名称 UNC1999 英文名称 UNC1999 规格或纯度 ≥98% 别名 UNC-1999;UNC 1999 英文别名 UNC-1999;UNC 1999;n-((1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl)-1-(1-methylethyl)-6-(6-(4-(1-methylethyl)-1-piperazinyl)-3-pyridinyl)-1h-indazole-4-carboxamide; 1-Isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-p 运输条件 超低温冰袋运输 生化机理 UNC1999 was the first orally bioavailable EZH2 inhibitor that has high in vitro potency for wild-type and mutant EZH2 as well as EZH1, UNC1999 was highly selective for EZH2 and EZH1 over a broad range of e
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CAS:1005342-46-0|LCL161
作者：德尔塔 日期：2022-03-14
产品名称 LCL161 英文名称 LCL161 规格或纯度 ≥99% 别名 LCL-161;LCL 161;(2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-propanamide;N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-(2S) 英文别名 LCL-161;LCL 161;(2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-propanamide;N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-(2S) 运输条件 超低温冰袋运输 生化机理
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CAS:65673-63-4|HA14-1
作者：德尔塔 日期：2022-03-14
产品名称 HA14-1 英文名称 HA14-1 应用 A cell-permeable, nonpeptidic Bcl-2 inhibitor 规格或纯度 ≥98% 别名 HA-14-1; HA 14-1 英文别名 HA-14-1; HA 14-1;2-amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphar,4r)-rel-4h-1-benzopyran-4-acetic acid ethyl ester；Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate 运输条件 超低温冰袋运输 生化机理 HA14-1 is a smal
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CAS:1257044-40-8|ABT-199 (GDC-0199)
作者：德尔塔 日期：2022-03-14
产品名称 ABT-199 (GDC-0199) 英文名称 ABT-199 (GDC-0199) 应用 A Bcl-2-selective inhibitor with Ki of
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CAS:873652-48-3|GDC-0152
作者：德尔塔 日期：2022-03-14
产品名称 GDC-0152 英文名称 GDC-0152 规格或纯度 98% 别名 L-Prolinamide, N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-;GDC0152, GDC 0152；(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide 英文别名 L-Prolinamide, N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-;GDC0152, GDC 0152；(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide 运输条件 超低温冰袋运输CAS编号 873652-48-3
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CAS:83373-60-8|O-三环[5.2.1.0 2,6 ] 癸基-9-二硫代碳酸酯 钾盐
作者：德尔塔 日期：2022-03-14
产品名称 O-三环[5.2.1.0 2,6 ] 癸基-9-二硫代碳酸酯 钾盐 英文名称 O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate potassium salt 应用 D609已被用作小鼠骨髓衍生的单核细胞中磷脂酰胆碱特异性磷脂酶C（PC-PLC）抑制剂。据报道，D609可以显著降低载脂蛋白 E-/-小鼠[1]中磷脂酰乙醇胺结合蛋白1（PEBP1）的水平升高。 规格或纯度 ≥98% 别名 D609 英文别名 D609 运输条件 超低温冰袋运输 生化机理 选择性竞争性
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CAS:803712-79-0|Obatoclax Mesylate
作者：德尔塔 日期：2022-03-14
产品名称 Obatoclax Mesylate 英文名称 Obatoclax Mesylate 应用 A novel Bcl-2 homology domain-3 (BH3) mimetic. 规格或纯度 ≥97% 别名 Obatoclax 甲磺酸盐 英文别名 GX15-070;2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate;2-[(5Z)-5-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-yl]-1H-indole mesylate 运输条件 超低温冰袋运输 生化机理 Bcl-2家族成员的抑制剂
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CAS:675576-98-4|Nutlin-3a
作者：德尔塔 日期：2022-03-14
产品名称 Nutlin-3a 英文名称 Nutlin-3a 规格或纯度 ≥97% 别名 (-)-Nutlin-3;2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]- 英文别名 (-)-Nutlin-3;2-Piperazinone, 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]- 运输条件 超低温冰袋运输 生化机理 Nutlin-3 is MDM2 antagonist. Nutlin-3 inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent;chemotherapeutic agent; induces apoptosis in cancer cell
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CAS:71555-25-4|NSC 319726
作者：德尔塔 日期：2022-03-14
产品名称 NSC 319726 英文名称 NSC 319726 规格或纯度 ≥95% 别名 NSC-319726 英文别名 NSC-319726；1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide；[1-(2-Pyridinyl)ethylidene]hydrazide 1-Azetidinecarbothioic Acid 运输条件 超低温冰袋运输 生化机理 NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells, shows 10- to 100-fold selectivity over the other hotspot p53 mutants. NSC319276 induces p53(R175)-m
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CAS:548472-68-0|Nutlin-3
作者：德尔塔 日期：2022-03-14
产品名称 Nutlin-3 英文名称 Nutlin-3 应用 Disrupts MDM2-p53 interaction, inducing apoptosis. 规格或纯度 ≥98% 别名 Nutlin 3;Nutlin3;4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one; 英文别名 Nutlin 3;Nutlin3;4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one; 运输条件 超低温冰袋运输 生化机理
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CAS:675576-97-3|Nutlin-3b
作者：德尔塔 日期：2022-03-14
产品名称 Nutlin-3b 英文名称 Nutlin-3b 规格或纯度 ≥98% 别名 Nutlin 3b 英文别名 Nutlin 3b;4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one ；(+)-Nutlin-3 运输条件 超低温冰袋运输 生化机理 Nutlin-3b is a 150-fold less potent (+)-enantiomer of Nutlin-3 as p53 MDM2 antagonist or inhibitor, in comparison with more potent opposite (-)-enantiomer Nutlin-3a. It is useful as a negative control for non-Mdm2 related cellular activities.CAS编号 675576-97-3
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CAS:114899-77-3|Trabectedin
作者：德尔塔 日期：2022-03-14
产品名称 Trabectedin 英文名称 Trabectedin 生化机理 Description:IC50 Value: 0.1-3.7 nM(breast cancer cell lines) [1]Trabectedin (Ecteinascidin-743 or ET-743) is a novel antitumour agent of marine origin with potent antitumour activity both in vitro and in vivo.in vitro: Trabectedin induced cytotoxicity and apoptosis in both breast cancer cells in a time and concentration-dependent manner. The expression levels of the death receptor pathway molecules, TRAIL-R1/DR4, TRAIL-R2/DR5, FAS/TNFRSF6, TNF RI/TNFRSF1A, and FADD were significantly increased by 2.6-, 3.1-, 1.7-, 11.2- and 4.0-fold by trabectedin treatment in MCF-7 cells. However, in MDA-MB-453 cells, the mitochondrial pathway related pro-apoptotic proteins Bax, Bad, Cytochrome c, Smac/DIABLO, and Cleaved Caspase-3 expressions were induced by 4.2-, 3.6-, 4.8-, 4.5-, and 4.4-fold, and the expression levels of anti-apoptotic proteins Bcl-2 and Bcl-XL were reduced by 4.8- and 5.2-fold in MDA-MB-453 cells [2]. In vitro treatment with noncytotoxic concentrations of trabectedin selectively inhibited the production of CCL2, CXCL8, IL-6, VEGF, and PTX3 by MLS primary tumor cultures and/or cell lines [3].in vivo: A xenograft mouse model of human MLS showed marked redu
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