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CAS:939981-39-2|RG7112
作者：德尔塔 日期：2022-03-14
产品名称 RG7112 英文名称 RG7112 规格或纯度 ≥98% 运输条件 超低温冰袋运输 生化机理 Restoration of p53 activity by inhibiting the p53-MDM2 interaction may represent a novel approach to cancer treatment. RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. In cancer cells expressing wild-type p53, RG7112 stabilizes p53 and activates the p53 pathway, leading to cell cycle arrest, apoptosis, and inhibition or regression of human tumor xenografts.Potent, orally bioavailable MDM2 inhibitor that displays antineoplastic activity. Nutlin imidazoline compound. RG-7112 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor proteCAS编号 939981-39-2
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CAS:781661-94-7|YM155 (Sepantronium Bromide)
作者：德尔塔 日期：2022-03-14
产品名称 YM155 (Sepantronium Bromide) 英文名称 YM155 (Sepantronium Bromide) 应用 An inhibitor of survivin expression and apoptosis inducer. 规格或纯度 ≥98% 别名 YM-155 英文别名 YM155; Sepantronium bromide;YM 155;YM-155;1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide;4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium br 运输条件 超低温冰袋运输 生
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CAS:1431866-33-9|WEHI-539
作者：德尔塔 日期：2022-03-14
产品名称 WEHI-539 英文名称 WEHI-539 生化机理 Description:IC50 Value: 1.1 nM (BCL-XL) [1]The prosurvival BCL-2 family protein BCL-XL is often overexpressed in solid tumors and renders malignant tumor cells resistant to anticancer therapeutics. The optimized compound, WEHI-539, has high affinity (subnanomolar) and selectivity for BCL-XL and potently kills cells by selectively antagonizing its prosurvival activity.WEHI-539 has a high affinity for BCL-XL (IC50 = 1.1 nM). WEHI-539 interacts with residues in the P4 pocket and adopts a distinct binding mode compared to ABT-737. WEHI-539 induces apoptosis in MEFs only if they lack MCL-1 supports the notion that cell killing induced by WEHI-539 is due to direct inhibition of BCL-XL. Accordingly, restoring expression of MCL-1 in mcl-1 knockout cells renders them highly resistant to WEHI-539. WEHI-539 could only kill cells that contained BAK (Fig. 6b). This observation was confirmed in MEFs where both the amount and activity of MCL-1 were abrogated by expression of its natural and selective BH3-only ligand NOXA. Cytochrome c release and caspase-3 processing confirmed that WEHI-539 induces apoptosis in BAX-deficient MEF cells expressing BIM2A but not in their BAK-deficien
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CAS:1260251-31-7|Birinapant
作者：德尔塔 日期：2022-03-14
产品名称 Birinapant 英文名称 Birinapant 规格或纯度 98% 别名 Propanamide, N,N'-[(6,6'-difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-, (2S,2'S)- 英文别名 Propanamide, N,N'-[(6,6'-difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-, (2S,2'S)- 运输条件 超低温冰袋运输 生化机理 cIAP1（Kd
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CAS:331244-89-4|BAM7
作者：德尔塔 日期：2022-03-14
产品名称 BAM7 英文名称 BAM7 规格或纯度 ≥99% 别名 3-甲基-1-(4-苯基-2-噻唑基)-1H-吡唑-4,5-二酮 4-[2-(2-乙氧基苯基)腙] 英文别名 BAM 7;BAM-7；4-(2-(2-Ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one；BAX activator molecule 7 运输条件 超低温冰袋运输 生化机理 Bax激活剂（EC50 =3.3μM）; 在BH3结合位点结合。对Bax的选择性高于其他抗凋亡蛋白和促凋亡蛋白。在体外触发Bax低聚；诱导小鼠胚胎成纤维细胞中Bax介导的凋亡。CAS编号 331244-89-4
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CAS:852808-04-9|ABT-737
作者：德尔塔 日期：2022-03-14
产品名称 ABT-737 英文名称 ABT-737 应用 A selective inhibitor of Bcl-2 规格或纯度 ≥97% 别名 ABT737;ABT 737 英文别名 ABT737;ABT 737;4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4- (dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl] sulfonylbenzamide 运输条件 超低温冰袋运输 生化机理 ABT-737 is a pan-Bcl-2 inhibitor that has a wide range of single-agent activity against acute lymp
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CAS:866541-93-7|AT101
作者：德尔塔 日期：2022-03-14
产品名称 AT101 英文名称 AT101 规格或纯度 ≥99% 别名 R-(-)-gossypol acetic acid;[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1) 英文别名 R-(-)-gossypol acetic acid;[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1) 运输条件 超低温冰袋运输CAS编号 866541-93-7
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CAS:1071992-99-8|AT406 (SM-406)
作者：德尔塔 日期：2022-03-14
产品名称 AT406 (SM-406) 英文名称 AT406 (SM-406) 规格或纯度 ≥98% 英文别名 (5S,8S,10aR,Z)-N-benzhydryl-5-((Z)-((S)-1-hydroxy-2-(methylamino)propylidene)amino)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carbimidic acid；ARRY-334543, Debio1143, SM-406 ;(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanami 运输条件 超低温冰袋运输 生化机理 AT-406 (formerly known as SM-406) is an orally bioavailable potent IAP (inhibitor of apoptosis protein) of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively. This may restore and promote the induction of apoptosis throμgh apoptotic signaling pathways. AT-406 may work synergistically with cytotoxic drμgs to overcome tumor cell resistance to apoptosi
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CAS:90141-22-3|AT-101
作者：德尔塔 日期：2022-03-14
产品名称 AT-101 英文名称 AT-101 别名 (-)-1，1′，6，6′，7，7′-Hexahydroxy-3，3′-dimethyl-5，5′-bis(1-methylethyl)-[2，2′-binaphthalene]-8，8′-dicarboxaldehyde，(R)-(-)-gossypol，(R)-1，1′，6，6′，7，7′-Hexahydroxy-3，3′-dimethyl-5，5′-bis( 英文别名 (-)-1，1′，6，6′，7，7′-Hexahydroxy-3，3′-dimethyl-5，5′-bis(1-methylethyl)-[2，2′-binaphthalene]-8，8′-dicarboxaldehyde，(R)-(-)-gossypol，(R)-1，1′，6，6′，7，7′-Hexahydroxy-3，3′-dimethyl-5，5′-bis( 运输条件 超低温冰袋运输 生化机理 AT-101 is orally bioavailable solvate of R-(-)-enantiomer of gossypol with potential antineoplastic activity. As a BH3 mimetic, AT-101 binds to the hydrophobic surface binding groove BH3 of the anti-apoptotic proteins Bcl-2 and Bcl-xL, blocking their hetero
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CAS:211364-78-2(free)|R18 TFA
作者：德尔塔 日期：2022-03-14
产品名称 R18 TFA 英文名称 R18 TFA 规格或纯度 98% 运输条件 超低温冰袋运输CAS编号 211364-78-2(free) 储存温度 -20°C储存 分子量 2423.69
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CAS:1807861-48-8|ONC212
作者：德尔塔 日期：2022-03-14
产品名称 N-三氟乙酰基-N-甲基-脱乙酰基秋水仙碱 英文名称 N-Trifluoroacetyl-N-methyl-deacetylcolchicine 运输条件 超低温冰袋运输CAS编号 1807861-48-8 溶解性 DMSO: 50 mg/mL (113.52 mM) 储存温度 -20°C储存 分子量 440.46
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CAS:173933-40-9|Hispolon
作者：德尔塔 日期：2022-03-14
产品名称 Hispolon 英文名称 Hispolon 规格或纯度 ≥98% 别名 (3Z,5E)-6-(3,4-dihydroxyphenyl)-4-hydroxy-hexa-3,5-dien-2-one 英文别名 (3Z,5E)-6-(3,4-dihydroxyphenyl)-4-hydroxy-hexa-3,5-dien-2-one 运输条件 超低温冰袋运输CAS编号 173933-40-9 溶解性 Soluble in DMSO.
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CAS:10341-88-5|3-苯基噻吩-2-羧酸
作者：德尔塔 日期：2022-03-14
产品名称 C6神经酰胺-13C2，d2 英文名称 C6 Ceramide-¹³C2,d2 规格或纯度 98% 运输条件 超低温冰袋运输CAS编号 10341-88-5 储存温度 室温 分子量 204.245
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CAS:93117-07-8|5-AIQ盐酸盐
作者：德尔塔 日期：2022-03-14
产品名称 5-AIQ盐酸盐 英文名称 5-AIQ hydrochloride 英文别名 5-Aminoisoquinolinone hydrochloride 运输条件 超低温冰袋运输CAS编号 93117-07-8 溶解性 Soluble in DMSO: >20 mg/mL and Water: >20 mg/mL 储存温度 -20°C储存
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CAS:91262-95-2|外毒素A，铜绿假单胞菌
作者：德尔塔 日期：2022-03-14
产品名称 外毒素A，铜绿假单胞菌 英文名称 Exotoxin A, Pseudomonas aeruginosa 运输条件 冰袋运输CAS编号 91262-95-2 溶解性 Soluble in water, 10 mM Tris-HCl, pH 8.0 (0.5 mg/ml), and neutral aqueous buffers (resulting in clear to slightly hazy, colorless solution). 储存温度 2-8°C储存 RTECS LF2991000
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